Systematic (IUPAC) name | |
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(RS)-N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide | |
Clinical data | |
Pregnancy cat. | ? |
Legal status | ? |
Identifiers | |
CAS number | 6673-35-4 |
ATC code | C07AB01 |
PubChem | CID 4883 |
IUPHAR ligand | 555 |
DrugBank | DB01297 |
ChemSpider | 4715 |
UNII | SUG9176GRW |
KEGG | D05587 |
ChEBI | CHEBI:258351 |
ChEMBL | CHEMBL6995 |
Chemical data | |
Formula | C14H22N2O3 |
Mol. mass | 266.336 g/mol |
SMILES | eMolecules & PubChem |
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Practolol (Eraldin, Dalzic, Praktol, Cardiol, Pralon, Cordialina, Eraldina, Teranol) is a selective beta blocker that has been used in the emergency treatment of cardiac arrhythmias. Practolol is no longer used as it is highly toxic despite the similarity of its chemical formula to propanolol. The use of practolol has been referred to as the practolol disaster and is considered the worst medical blunders since thalidomide.
Side effects are similar to those of other beta blockers, such as bronchoconstriction, cardiac failure, cold extremities, fatigue and depression, hypoglycaemia.[1]
Furthermore, chronic use of practolol may cause oculomucocutaneous syndrome,[1] a severe syndrome whose signs include conjunctivitis sicca and psoriasiform rashes, otitis and sclerosing serositis. This syndrome has not been observed with other such beta blockers.[2]